Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide.

@article{Mukoyama1991BrainNP,
  title={Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide.},
  author={Masashi Mukoyama and K. Nakao and Kiminori Hosoda and Sadao Suga and Yuki Saito and Yoshihiro Ogawa and Gotaro Shirakami and Michihisa Jougasaki and Kouji Obata and Hirofumi Yasue},
  journal={The Journal of clinical investigation},
  year={1991},
  volume={87 4},
  pages={1402-12}
}
Using a specific radioimmunoassay for human brain natriuretic peptide (hBNP) with a monoclonal antibody, we have investigated its synthesis, secretion, and clearance in comparison with those of atrial natriuretic peptide (ANP) in normal subjects and patients with congestive heart failure (CHF). Mean BNP-like immunoreactivity (-LI) levels in normal atrium and ventricle were 250 and 18 pmol/g, respectively. The plasma BNP-LI level in normal subjects was 0.90 +/- 0.07 fmol/ml, which was 16% of the… CONTINUE READING
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