Brain monoamines and antidepressant-like responses in MRL/MpJ versus C57BL/6J mice

@article{Balu2013BrainMA,
  title={Brain monoamines and antidepressant-like responses in MRL/MpJ versus C57BL/6J mice},
  author={Darrick T Balu and Jill R Turner and Bethany R. Brookshire and Tiffany E. Hill-Smith and Julie A. Blendy and Irwin Lucki},
  journal={Neuropharmacology},
  year={2013},
  volume={67},
  pages={503-510}
}
The MRL/MpJ mouse demonstrates enhanced wound healing and tissue regeneration and increased neurotrophic mobilization to chronic antidepressant drug treatments. This study compared brain monoamine systems between MRL/MpJ and C57BL/6J mice as a potential basis for strain differences after chronic antidepressant treatment. MRL/MpJ mice had significantly higher tissue levels of serotonin and dopamine in multiple brain regions. Microdialysis studies demonstrated that baseline levels of… CONTINUE READING