Brain molecular aging, promotion of neurological disease and modulation by Sirtuin5 longevity gene polymorphism

@article{Glorioso2011BrainMA,
  title={Brain molecular aging, promotion of neurological disease and modulation by Sirtuin5 longevity gene polymorphism},
  author={Christin Glorioso and Sunghee Oh and Gaelle Guilloux Douillard and Etienne Sibille},
  journal={Neurobiology of Disease},
  year={2011},
  volume={41},
  pages={279-290}
}
Mechanisms determining characteristic age-of-onset for neurological diseases are largely unknown. Normal brain aging associates with robust and progressive transcriptome changes ("molecular aging"), but the intersection with disease pathways is mostly uncharacterized. Here, using cross-cohort microarray analysis of four human brain areas, we show that neurological disease pathways largely overlap with molecular aging and that subjects carrying a newly-characterized low-expressing polymorphism… CONTINUE READING
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