Brain mitochondrial dysfunction in aging.


Aging of mammalian brain is associated with a continuous decrease of the capacity to produce ATP by oxidative phosphorylation. The impairment of mitochondrial function is mainly due to diminished electron transfer by complexes I and IV, whereas inner membrane H+ impermeability and F1-ATP synthase activity are only slightly affected. Dysfunctional… (More)
DOI: 10.1002/iub.46


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@article{Boveris2008BrainMD, title={Brain mitochondrial dysfunction in aging.}, author={Alberto Boveris and Ana M Navarro}, journal={IUBMB life}, year={2008}, volume={60 5}, pages={308-14} }