Brain microvessel cross-presentation is a hallmark of experimental cerebral malaria

@inproceedings{Howland2013BrainMC,
  title={Brain microvessel cross-presentation is a hallmark of experimental cerebral malaria},
  author={Shanshan W Howland and Chek Meng Poh and Sin Yee Gun and Carla Claser and Benoit Malleret and Nilabh Shastri and Florent Ginhoux and Gijsbert M. Grotenbreg and Laurent R{\'e}nia},
  booktitle={EMBO molecular medicine},
  year={2013}
}
Cerebral malaria is a devastating complication of Plasmodium falciparum infection. Its pathogenesis is complex, involving both parasite- and immune-mediated events. CD8(+) T cells play an effector role in murine experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA (PbA) infection. We have identified a highly immunogenic CD8 epitope in glideosome-associated protein 50 that is conserved across rodent malaria species. Epitope-specific CD8(+) T cells are induced during PbA… CONTINUE READING
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