Brain microglia were activated in sporadic CJD but almost unchanged in fatal familial insomnia and G114V genetic CJD

@inproceedings{Shi2013BrainMW,
  title={Brain microglia were activated in sporadic CJD but almost unchanged in fatal familial insomnia and G114V genetic CJD},
  author={Qi Shi and Wu-ling Xie and Baoyun Zhang and Li-na Chen and Yin Xu and Ke Wang and Ke Ren and Xiao-mei Zhang and Cao Chen and Jin Zhang and Xiao-Ping Dong},
  booktitle={Virology Journal},
  year={2013}
}
BackgroundMicroglial activations have been described in different subtypes of human prion diseases such as sporadic Creutzfeldt-Jakob disease (CJD), variant CJD, Kuru and Gerstmann-Sträussler-Scheinker disease (GSS). However, the situation of microglia in other genetic prion diseases such as fatal familial insomnia (FFI) and familial CJD remains less understood. The brain microglia was evaluated comparatively between the FFI, G114V and sCJD cases in the study.MethodsSpecific Western blots… CONTINUE READING
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