Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood–brain barrier

@inproceedings{Tominaga2015BrainMC,
  title={Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood–brain barrier},
  author={Naoomi Tominaga and Nobuyoshi Kosaka and Makiko Ono and Takeshi Katsuda and Yusuke Yoshioka and Kenji Tamura and Jan L{\"o}tvall and Hitoshi Nakagama and Takahiro Ochiya},
  booktitle={Nature communications},
  year={2015}
}
Brain metastasis is an important cause of mortality in breast cancer patients. A key event during brain metastasis is the migration of cancer cells through blood-brain barrier (BBB). However, the molecular mechanism behind the passage through this natural barrier remains unclear. Here we show that cancer-derived extracellular vesicles (EVs), mediators of cell-cell communication via delivery of proteins and microRNAs (miRNAs), trigger the breakdown of BBB. Importantly, miR-181c promotes the… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 66 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 95 extracted citations

Similar Papers

Loading similar papers…