Brain metabolic changes suggestive of axonal damage in radiologically isolated syndrome.

@article{Stromillo2013BrainMC,
  title={Brain metabolic changes suggestive of axonal damage in radiologically isolated syndrome.},
  author={Maria Laura Stromillo and Antonio Giorgio and Francesca Rossi and Marco Battaglini and Bahia Hakiki and Gianmichele Malentacchi and Mario Luigi Santangelo and Claudio Gasperini and Maria Letizia Bartolozzi and Emilio Portaccio and Maria Pia Amato and A Giorgio},
  journal={Neurology},
  year={2013},
  volume={80 23},
  pages={2090-4}
}
BACKGROUND The MRI incidental finding in asymptomatic subjects of brain white matter (WM) changes meeting the Barkhof criteria for the diagnosis of multiple sclerosis (MS) has been recently characterized as the radiologically isolated syndrome (RIS). This entity needs to be more specifically defined to allow risk stratification of these subjects. We used brain proton magnetic resonance spectroscopic imaging (1H-MRSI) to assess metabolic changes in an RIS population. METHODS Twenty-three RIS… CONTINUE READING
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