Brain mechanisms that control sleep and waking

  title={Brain mechanisms that control sleep and waking},
  author={Jerome Siegel},
This review paper presents a brief historical survey of the technological and early research that laid the groundwork for recent advances in sleep–waking research. A major advance in this field occurred shortly after the end of World War II with the discovery of the ascending reticular activating system (ARAS) as the neural source in the brain stem of the waking state. Subsequent research showed that the brain stem activating system produced cortical arousal via two pathways: a dorsal route… CONTINUE READING


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