Brain mechanisms associated with depressive relapse and associated cognitive impairment following acute tryptophan depletion.

@article{Smith1999BrainMA,
  title={Brain mechanisms associated with depressive relapse and associated cognitive impairment following acute tryptophan depletion.},
  author={Katharine A Smith and John S. Morris and Karl J. Friston and Philip J. Cowen and Raymond J. Dolan},
  journal={The British journal of psychiatry : the journal of mental science},
  year={1999},
  volume={174},
  pages={
          525-9
        }
}
BACKGROUND Acute tryptophan depletion lowers brain serotonin synthesis and results in a transient, but striking, clinical relapse in recovered depressed patients. AIMS To identify brain regions which change their activity as an acute depressive relapse evolves and to determine how pathological mood might modulate neural activity during a cognitive task. METHOD We used H2(15)O positron-emission tomography (PET) to study eight recovered depressed men after tryptophan depletion and after a… CONTINUE READING
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Therdeofthe cinguh gyna in depression : from functional aMtomy to rmrochani

  • A. Honig. M. Ansseau

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