Brain magnetic resonance imaging with contrast dependent on blood oxygenation.

@article{Ogawa1990BrainMR,
  title={Brain magnetic resonance imaging with contrast dependent on blood oxygenation.},
  author={Seiji Ogawa and T. M. Lee and A R Kay and David W. Tank},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 24},
  pages={
          9868-72
        }
}
  • S. Ogawa, T. Lee, D. Tank
  • Published 1 December 1990
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences of the United States of America
Paramagnetic deoxyhemoglobin in venous blood is a naturally occurring contrast agent for magnetic resonance imaging (MRI). By accentuating the effects of this agent through the use of gradient-echo techniques in high fields, we demonstrate in vivo images of brain microvasculature with image contrast reflecting the blood oxygen level. This blood oxygenation level-dependent (BOLD) contrast follows blood oxygen changes induced by anesthetics, by insulin-induced hypoglycemia, and by inhaled gas… 

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References

SHOWING 1-10 OF 14 REFERENCES
Brain imaging and brain function.
  • B. A. Holland
  • Biology
    Research publications - Association for Research in Nervous and Mental Disease
  • 1985
Biochim. Biophys. Acta
  • Biochim. Biophys. Acta
  • 1982
Magn. Reson. Med
  • Magn. Reson. Med
  • 1990
Magn. Reson. Med
  • Magn. Reson. Med
  • 1990
Brain Imaging and Brain Function (Raven
  • 1985
Magn. Reson. Med
  • Magn. Reson. Med
  • 1990
Proc. Nail. Acad. Sci. USA 85
  • Proc. Nail. Acad. Sci. USA 85
  • 1988
Magn. Reson. Med
  • Magn. Reson. Med
  • 1990
Magn. Reson. Med
  • Magn. Reson. Med
  • 1990
...
...