Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [11C]ABP688 PET imaging and ex vivo immunoblotting

Abstract

Alzheimer's disease (AD) is characterized by aggregation of amyloid beta (Aβ) into insoluble plaques. Intermediates, Aβ oligomers (Aβo), appear to be the mechanistic cause of disease. The de facto PET AD ligand, [11C]PIB, binds and visualizes Aβ plaque load, which does not correlate well with disease severity. Therefore, finding a dynamic target that… (More)
DOI: 10.1016/j.neuropharm.2016.10.009

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@article{Fang2017BrainMI, title={Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [11C]ABP688 PET imaging and ex vivo immunoblotting}, author={Xiaotian T. Fang and Jonas Eriksson and Gunnar Antoni and Ulrika Yngve and Linda Cato and Lars Lannfelt and Dag Sehlin and Stina Syv{\"a}nen}, journal={Neuropharmacology}, year={2017}, volume={113}, pages={293-300} }