Brain lipopigment accumulation in normal and pathological aging.

  title={Brain lipopigment accumulation in normal and pathological aging.},
  author={Dan Riga and Sorin Riga and Florin Halalau and Francisc Schneider},
  journal={Annals of the New York Academy of Sciences},
A principal marker of brain vulnerability, stress, aging, and related pathology is represented by lipopigments (LPs)--lipofuscin, and ceroid. During ontogenesis, neuronal LP accumulations are significantly correlated with important changes in nerve cell morphology and biochemistry. In the aged neurons, LPs are present in all cellular compartments. Moreover, neuronal LP accumulations coexist with glial LP storage, especially in microglia. Owing to their transporting properties, and the migration… CONTINUE READING
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