Brain lipid peroxidation and antioxidant protectant mechanisms following acute cyanide intoxication.

@article{Ardelt1989BrainLP,
  title={Brain lipid peroxidation and antioxidant protectant mechanisms following acute cyanide intoxication.},
  author={Barbara K. Ardelt and Joseph L Borowitz and Gary E. Isom},
  journal={Toxicology},
  year={1989},
  volume={56 2},
  pages={
          147-54
        }
}
The status of brain antioxidant enzymes and glutathione levels in mice intoxicated with KCN were correlated with lipid peroxidation in brain membranes. KCN (7 mg/kg, s.c.) rapidly increased conjugated dienes in brain lipids, with peak levels observed 30 min after cyanide treatment. At 60 min post cyanide, conjugated diene levels were only slightly elevated above controls. Temporal changes in activity of most antioxidant enzymes corresponded with the observed time course of cyanide-induced… CONTINUE READING

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