Brain levels and acetylcholinesterase inhibition with galantamine and donepezil in rats, mice, and rabbits.

@article{Geerts2005BrainLA,
  title={Brain levels and acetylcholinesterase inhibition with galantamine and donepezil in rats, mice, and rabbits.},
  author={Hugo Geerts and Pierre-Olivier Guillaumat and Christopher G. Grantham and Wilhelmina Bode and Katelijne Anciaux and Sohel Sachak},
  journal={Brain research},
  year={2005},
  volume={1033 2},
  pages={186-93}
}
Galantamine is a rather weak acetylcholinesterase (AChE) inhibitor, currently approved for the symptomatic treatment of Alzheimer's disease, with possible additional allosteric potentiating effects at the nicotinic ACh receptor (nAChR). Earlier data from in vitro biochemical tests suggest that donepezil is 40- to 500-fold more potent than galantamine in inhibiting AChE. In this study, both brain levels and Ki values for AChE inhibition for donepezil and galantamine in rat, mouse, and rabbit… CONTINUE READING

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