Brain lesions following combined treatment with methotrexate and craniospinal irradiation

@article{CruzSnchez1991BrainLF,
  title={Brain lesions following combined treatment with methotrexate and craniospinal irradiation},
  author={Felix F. Cruz-S{\'a}nchez and J. M. Gatell Artigas and Jorge Cerv{\'o}s-Navarro and Marco Luciano Rossi and Ron Ferszt},
  journal={Journal of Neuro-Oncology},
  year={1991},
  volume={10},
  pages={165-171}
}
Eight patients with meningeal seeding by carcinoma or lymphomas were treated with intravenous (i.v.) and/or intrathecal (i.th.) Methotrexate (MTX). Seven patients received additional craniospinal irradiation and in all seven a fatal encephalopathy developed. On the bases of clinical and morphological findings we identified an acute and a delayed form of encephalopathy and concluded that the concurrent administration of Methotrexate and of craniospinal irradiation increases considerably the risk… CONTINUE READING
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