Brain kinetics of methylphenidate (Ritalin) enantiomers after oral administration.

  title={Brain kinetics of methylphenidate (Ritalin) enantiomers after oral administration.},
  author={Yu-Shin Ding and Samuel John Gatley and Panayotis K. Thanos and Colleen Shea and V{\'i}ctor M Garza and Youwen Xu and Pauline Carter and Payton King and Don Warner and Nicholas B Taintor and Daniel J. Park and Bea Pyatt and Joanna S. Fowler and Nora D. Volkow},
  volume={53 3},
Methylphenidate (MP) (Ritalin) is widely used for the treatment of attention deficit hyperactivity disorder (ADHD). It is a chiral drug, marketed as the racemic mixture of d- and l-threo enantiomers. Our previous studies (PET and microdialysis) in humans, baboons, and rats confirm the notion that pharmacological specificity of MP resides predominantly in the d-isomer. A recent report that intraperitoneally (i.p.) administered l-threo-MP displayed potent, dose-dependent inhibition of cocaine- or… CONTINUE READING
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