Brain iron pathways and their relevance to Parkinson's disease.

@article{Berg2001BrainIP,
  title={Brain iron pathways and their relevance to Parkinson's disease.},
  author={Daniela Berg and Manfred Gerlach and Moussa B. H. Youdim and Kay L Double and Luigi Zecca and Peter Franz Riederer and Guillaume Becker},
  journal={Journal of neurochemistry},
  year={2001},
  volume={79 2},
  pages={225-36}
}
A central role of iron in the pathogenesis of Parkinson's disease (PD), due to its increase in substantia nigra pars compacta dopaminergic neurons and reactive microglia and its capacity to enhance production of toxic reactive oxygen radicals, has been discussed for many years. Recent transcranial ultrasound findings and the observation of the ability of iron to induce aggregation and toxicity of alpha-synuclein have reinforced the critical role of iron in the pathogenesis of nigrostriatal… CONTINUE READING