Brain intra- and extracellular sodium concentration in multiple sclerosis: a 7 T MRI study.

  title={Brain intra- and extracellular sodium concentration in multiple sclerosis: a 7 T MRI study.},
  author={Maria Petracca and Roxana Vancea and L. Fleysher and Laura E. Jonkman and N. Oesingmann and Matilde Inglese},
  journal={Brain : a journal of neurology},
  volume={139 Pt 3},
Intra-axonal accumulation of sodium ions is one of the key mechanisms of delayed neuro-axonal degeneration that contributes to disability accrual in multiple sclerosis. In vivo sodium magnetic resonance imaging studies have demonstrated an increase of brain total sodium concentration in patients with multiple sclerosis, especially in patients with greater disability. However, total sodium concentration is a weighted average of intra- and extra-cellular sodium concentration whose changes reflect… 

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