Brain insulin and leptin signaling in metabolic control: from animal research to clinical application.

@article{Scherer2013BrainIA,
  title={Brain insulin and leptin signaling in metabolic control: from animal research to clinical application.},
  author={Thomas A. Scherer and Hendrik Lehnert and Manfred Hallschmid},
  journal={Endocrinology and metabolism clinics of North America},
  year={2013},
  volume={42 1},
  pages={
          109-25
        }
}
Besides the well-characterized effects of brain insulin and leptin in regulating food intake, insulin and leptin signaling to the central nervous system modulates a variety of metabolic processes, such as glucose and lipid homeostasis, as well as energy expenditure. This review summarizes the current literature on the contribution of central nervous insulin and leptin action to metabolic control in animals and humans. Potential therapeutic options based on the direct delivery of these peptides… CONTINUE READING
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