Brain infarction and the clinical expression of Alzheimer disease. The Nun Study.

@article{Snowdon1997BrainIA,
  title={Brain infarction and the clinical expression of Alzheimer disease. The Nun Study.},
  author={David A. Snowdon and Leonie Greiner and James A. Mortimer and Kathryn P Riley and Philip A Greiner and William R. Markesbery},
  journal={JAMA},
  year={1997},
  volume={277 10},
  pages={813-7}
}
OBJECTIVE To determine the relationship of brain infarction to the clinical expression of Alzheimer disease (AD). DESIGN Cognitive function and the prevalence of dementia were determined for participants in the Nun Study who later died. At autopsy, lacunar and larger brain infarcts were identified, and senile plaques and neurofibrillary tangles in the neocortex were quantitated. Participants with abundant senile plaques and some neurofibrillary tangles in the neocortex were classified as… CONTINUE READING
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