Brain in Congenital Heart Disease Across the Lifespan: The Cumulative Burden of Injury.

@article{Marelli2016BrainIC,
  title={Brain in Congenital Heart Disease Across the Lifespan: The Cumulative Burden of Injury.},
  author={Ariane J Marelli and Steven Paul Miller and Bradley Scott Marino and Angela Lee Jefferson and Jane W. Newburger},
  journal={Circulation},
  year={2016},
  volume={133 20},
  pages={1951-62}
}
The number of patients surviving with congenital heart disease (CHD) has soared over the last 3 decades. Adults constitute the fastest-growing segment of the CHD population, now outnumbering children. Research to date on the heart-brain intersection in this population has been focused largely on neurodevelopmental outcomes in childhood and adolescence. Mutations in genes that are highly expressed in heart and brain may cause cerebral dysgenesis. Together with altered cerebral perfusion in utero… CONTINUE READING
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