Brain imaging of serotonin after recovery from anorexia and bulimia nervosa

@article{Kaye2005BrainIO,
  title={Brain imaging of serotonin after recovery from anorexia and bulimia nervosa},
  author={Walter H. Kaye and Ursula F. Bailer and Guido K. W. Frank and Angela Wagner and Shannan Henry},
  journal={Physiology \& Behavior},
  year={2005},
  volume={86},
  pages={15-17}
}
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79 Citations

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References

SHOWING 1-10 OF 19 REFERENCES

Reduced 5-HT2A receptor binding after recovery from anorexia nervosa

Implications of impulsive and affective symptoms for serotonin function in bulimia nervosa

The observations link bulimia nervosa to altered 5-HT functioning, and suggest that there may be a relatively symptom-specific association between impulsivity and reduced 5- HT reuptake.

Altered 5-HT2A Receptor Binding after Recovery from Bulimia-Type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness

Research suggests that altered 5-HT neuronal system activity persists after recovery from bulimia-type AN, particularly in subgenual cingulate regions, and supports the possibility that this may be a trait-related disturbance that contributes to the pathophysiology of eating disorders.

Altered brain serotonin 5-HT1A receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [carbonyl11C]WAY-100635.

For women recovered from restricting-type AN, the 5-HT1A postsynaptic receptor binding in mesial temporal and subgenual cingulate regions was positively correlated with harm avoidance and 4-HT system alterations may be trait related and may contribute to the pathogenesis of AN.

Decreased serotonin function in bulimia nervosa.

This study provides new evidence that impaired central nervous system serotonergic responsiveness may contribute to the onset or maintenance of abnormal eating patterns in patients with bulimia nervosa.

Brain serotonin 1A receptor binding in bulimia nervosa

The genetic epidemiology of bulimia nervosa.

The liability to fully syndromal bulimia nervosa, which affects around one in 25 women at some point in their lives, is substantially influenced by both epidemiologic and genetic risk factors.

Decreased 5-HT2a receptor binding in patients with anorexia nervosa.

Patients with AN had a significantly reduced 5-HT(2a) binding index, in accordance with diminished metabolic and perfusion of frontal and parietal cortices reported in recent neuroimaging studies, and imply localized disturbed serotonergic function.

Serotonin receptors : their key role in drugs to treat schizophrenia

The Neurobiology of Mental Illness

Loaded with 32 new chapters and a completely revamped edition with new section editors and authors Cutting edge synthesis of genetics, epigenetics, neurobiology, from animal models to human…