Brain imaging of serotonin after recovery from anorexia and bulimia nervosa

  title={Brain imaging of serotonin after recovery from anorexia and bulimia nervosa},
  author={Walter H. Kaye and Ursula F. Bailer and Guido K. W. Frank and Angela Wagner and Shannan Henry},
  journal={Physiology \& Behavior},

SPECT and PET in Eating Disorders

Assessment of functional changes in the brain with PET or SPECT may have prognostic value and predict neuropsychological status after several years of therapy.

Molecular bases of anorexia nervosa, bulimia nervosa and binge eating disorder: shedding light on the darkness

This review presents an overview concerning the actual pharmacological and psychological treatments, the knowledge of cells, circuits, neuropeptides, neuromodulators and hormones in the human brain- and other organs- underlying these disorders, the studies in animal models and, finally, the genetic approaches devoted to face this challenge.

The effects of acute tryptophan depletion on instrumental reward learning in anorexia nervosa - an fMRI study.

BACKGROUND The serotonin (5-HT) hypothesis of anorexia nervosa (AN) posits that individuals predisposed toward or recovered from AN (recAN) have a central nervous hyperserotonergic state and

A Review of Anorexia Nervosa, Its Relationship to Autism and Borderline Personality Disorder, and Implications for Patient Related Outcomes

Anorexia Nervosa (AN) is a serious psychiatric disorder associated with reduced intake of food, increased energy expenditure and psychological features, in which a low body weight is deliberately

Functional magnetic resonance studies in eating behavior disorders.

Some alterations and changes in metabolism and blood perfusion that accompany the neuroimaging findings will be reviewed, as well as studies designed to determine whether these alterations persist after recovery from the disease.

Association study in eating disorders: TPH2 associates with anorexia nervosa and self‐induced vomiting

The association of 25 single nucleotide polymorphisms (SNPs) was investigated, revealing that the tryptophan hydroxylase 2 polymorphism rs1473473 was associated with a higher risk for AN, EDs characterized by SV and for the combined group.

Under- to over-eating: how do serotonin receptors contribute?

A recent snapshot of the neural underpinnings of the rewarding effects of anorexia that may compete with the adaptive decision-making process to eat, and with survival instinct is provided.

From Disordered Eating to Addiction: The “Food Drug” in Bulimia Nervosa

Neurobiological findings support the notion that BN is an addictive disorder, which has treatment implications for therapy and pharmacological manipulations.

Neurobiological and Psychopathological Variables Related to Emotional Instability: A Study of Their Capability to Discriminate Patients with Bulimia Nervosa from Healthy Controls

The results suggest that hypothalamic-pituitary-adrenal axis activity, dopamine activity and other biological parameters are worthy of further study as potential dimensional markers of BN, although they seem to depend on the psychopathological status of the patients.



Implications of impulsive and affective symptoms for serotonin function in bulimia nervosa

The observations link bulimia nervosa to altered 5-HT functioning, and suggest that there may be a relatively symptom-specific association between impulsivity and reduced 5- HT reuptake.

Altered 5-HT2A Receptor Binding after Recovery from Bulimia-Type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness

Research suggests that altered 5-HT neuronal system activity persists after recovery from bulimia-type AN, particularly in subgenual cingulate regions, and supports the possibility that this may be a trait-related disturbance that contributes to the pathophysiology of eating disorders.

Altered brain serotonin 5-HT1A receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [carbonyl11C]WAY-100635.

For women recovered from restricting-type AN, the 5-HT1A postsynaptic receptor binding in mesial temporal and subgenual cingulate regions was positively correlated with harm avoidance and 4-HT system alterations may be trait related and may contribute to the pathogenesis of AN.

Decreased serotonin function in bulimia nervosa.

This study provides new evidence that impaired central nervous system serotonergic responsiveness may contribute to the onset or maintenance of abnormal eating patterns in patients with bulimia nervosa.

Brain serotonin 1A receptor binding in bulimia nervosa

The genetic epidemiology of bulimia nervosa.

The liability to fully syndromal bulimia nervosa, which affects around one in 25 women at some point in their lives, is substantially influenced by both epidemiologic and genetic risk factors.

Decreased 5-HT2a receptor binding in patients with anorexia nervosa.

Patients with AN had a significantly reduced 5-HT(2a) binding index, in accordance with diminished metabolic and perfusion of frontal and parietal cortices reported in recent neuroimaging studies, and imply localized disturbed serotonergic function.

Serotonin receptors : their key role in drugs to treat schizophrenia

The Neurobiology of Mental Illness

Loaded with 32 new chapters and a completely revamped edition with new section editors and authors Cutting edge synthesis of genetics, epigenetics, neurobiology, from animal models to human