Brain imaging of serotonin 4 receptors in humans with [<ce:sup loc=post>11</ce:sup>C]SB207145-PET

  title={Brain imaging of serotonin 4 receptors in humans with [<ce:sup loc=post>11</ce:sup>C]SB207145-PET},
  author={Lisbeth Marner and Nic Gillings and Karine Madsen and David Erritzoe and William F. C. Baar{\'e} and Claus Svarer and Steen G. Hasselbalch and Gitte Moos Knudsen},
Pharmacological stimulation of the serotonin 4 (5-HT(4)) receptor has shown promise for treatment of Alzheimer's disease and major depression. A new selective radioligand, [(11)C]SB207145, for positron emission tomography (PET) was used to quantify brain 5-HT(4) receptors in sixteen healthy subjects (20-45 years, 8 males) using the simplified reference tissue model. We tested within our population the effect of age and other demographic factors on the endpoint. In seven subjects, we tested the… CONTINUE READING


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Kinetic modeling

  • L. Marner, N. Gillings, +9 authors G. M. Knudsen
  • 2009
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