Brain imaging in catatonia: systematic review and directions for future research

  title={Brain imaging in catatonia: systematic review and directions for future research},
  author={Alexandre Haroche and Jonathan P. Rogers and Marion Plaze and Raphael Gaillard and Steve C.R. Williams and Pierre Thomas and Ali Amad},
  journal={Psychological Medicine},
  pages={1585 - 1597}
Abstract Background Catatonia is a frequent, complex and severe identifiable syndrome of motor dysregulation. However, its pathophysiology is poorly understood. Methods We aimed to provide a systematic review of all brain imaging studies (both structural and functional) in catatonia. Results We identified 137 case reports and 18 group studies representing 186 individual patients with catatonia. Catatonia is often associated with brain imaging abnormalities (in more than 75% of cases). The… 

Catatonia in older adults: A systematic review

BACKGROUND Catatonia is a complex psychomotor syndrome that often goes unrecognized and untreated, even though its classification has evolved in recent years. Prompt and correct identification of

Efficacy of Transcranial Direct-Current Stimulation in Catatonia: A Review and Case Series

Results indicate that tDCS, in addition to symptomatic pharmacotherapies such as lorazepam, seems to effectively reduce catatonic symptoms, corroborate a synthesis of five previous case reports of catatonia treated by tDCS in the literature.

Resting state functional connectivity and structural abnormalities of the brain in acute retarded catatonia: an exploratory MRI study

Neuroimaging markers of the acute retarded catatonic state that may show an association with treatment response to benzodiazepines are identified and discuss how these novel findings have important translational implications for understanding the pathophysiology of catatonia as well as for the mechanistic understanding and prediction of treatment Response to Benzodiazepine.

The fMRI signature of acute catatonic state and its response to benzodiazepines

Functional MRI markers that characterize the acute retarded catatonic state and predict treatment response are identified and discuss how these novel findings have important translational implications for understanding the pathophysiology of catatonia and for predicting treatment response to benzodiazepines.

Covid-19 Induced Catatonia: A Review Of This Rare Phenomenon.

COVID-19 should be considered as one of the major factors in this complex psychiatric disease, catatonia, because of the multiple etiologies associated with this presentation.

Clinical features and predictors of non-response in severe catatonic patients treated with electroconvulsive therapy

The association between ECT resistant catatonia and neurological comorbidity, use of dopamine-agonist and anticholinergic medications is consistent with the hypothesis that ECT is more effective in ‘top-down’ than in � ‘bottom-up’ variant of cat atonia.

Pediatric Malignant Catatonia Associated With Vaporized Cannabis Use: A Case Series.

Application of positron emission tomography in psychiatry—methodological developments and future directions

Mental disorders represent an increasing source of disability and high costs for societies globally. Molecular imaging techniques such as positron emission tomography (PET) represent powerful tools



Brain Imaging in Catatonia: Current Findings and a Pathophysiologic Model

Brain imaging studies have shown major and specific alterations in a right hemispheric neural network that includes the medial and lateral orbitofrontal and posterior parietal cortex that may be abnormally modulated by altered functional interactions between γ-aminobutyric acid-ergic and glutamatergic transmission.

Structure and neural mechanisms of catatonia.

Multimodal Magnetic Resonance Imaging Data Fusion Reveals Distinct Patterns of Abnormal Brain Structure and Function in Catatonia.

A multivariate data fusion technique for multimodal magnetic resonance imaging data is used to investigate patterns of aberrant intrinsic neural activity (INA) and gray matter volume (GMV) in SSD patients with and without catatonia, suggesting co-altered structure/function-interactions in neural systems subserving coordinated visuospatial functions and motor behavior.

Resting-State Hyperperfusion of the Supplementary Motor Area in Catatonia

Resting-state cerebral blood flow (rCBF) and gray matter (GM) density between schizophrenia patients with current catatonia and without cat atonia and healthy controls is compared to argue for distinct pathobiology.

Catatonia and neuroleptic malignant syndrome: psychopathology and pathophysiology

  • G. Northoff
  • Psychology, Medicine
    Journal of Neural Transmission
  • 2002
One may characterize catatonia as a cortical “psychomotor syndrome” while NMS may rather be regarded as subcortical “motor Syndrome”.

Cortical Contributions to Distinct Symptom Dimensions of Catatonia.

T1-weighted structural magnetic resonance imaging data at 3 T were obtained from 56 right-handed patients with SSD and support the notion that cortical features of distinct evolutionary and genetic origin differently contribute to catatonia in SSD.

Right lower prefronto-parietal cortical dysfunction in akinetic catatonia: a combined study of neuropsychology and regional cerebral blood flow

Findings are preliminary but suggest right lower prefronto-parietal cortical dysfunction in catatonia, which may be closely related to psychomotor disturbances.

What catatonia can tell us about “top-down modulation”: A neuropsychiatric hypothesis

  • G. Northoff
  • Psychology, Biology
    Behavioral and Brain Sciences
  • 2002
It is hypothesized that similarities and differences between Parkinson's disease and catatonia may be accounted for by distinct kinds of modulation between Cortico-cortical and cortico-subcortic relations.

Cortical sulcal enlargement in catatonic schizophrenia: a planimetric CT study

Catatonia and neuroleptic malignant syndrome: two sides of a coin?

Five cases of catatonia and NMS are described in order to approach the nosological question of whether the syndrome is to be considered a syndrome with a wide variety of causes and clinical signs or a distinct clinical entity and the clinical similarity between both syndromes.