Brain imaging and human nutrition: which measures to use in intervention studies?

  title={Brain imaging and human nutrition: which measures to use in intervention studies?},
  author={St{\'e}phane V. Sizonenko and Claudio Babiloni and Eveline De bruin and Elizabeth B. Isaacs and Lena S. J{\"o}nsson and David O. Kennedy and Marie E Latulippe and M. Hasan Mohajeri and Judith Moreines and Pietro Pietrini and Kristine Beate Walhovd and R. J. Winwood and John W. C. Sijben},
  journal={British Journal of Nutrition},
  pages={S1 - S30}
The present review describes brain imaging technologies that can be used to assess the effects of nutritional interventions in human subjects. Specifically, we summarise the biological relevance of their outcome measures, practical use and feasibility, and recommended use in short- and long-term nutritional studies. The brain imaging technologies described consist of MRI, including diffusion tensor imaging, magnetic resonance spectroscopy and functional MRI, as well as electroencephalography… 
Brain imaging and human nutrition: which measures to use in intervention studies?
The utility of existing brain imaging technologies to assess the effects of nutritional intervention in humans is described and examples of current research showing the utility of these markers are reviewed.
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A blueprint for a more targeted approach to the design of RCT in nutrition, cognition and brain health in ageing is offered that focuses on three key areas: the role of nutrition is more suited for the maintenance of health rather than the treatment of disease, and those that especially deteriorate in senescence should be focal points in evaluating the efficacy of an intervention.
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A primer for brain imaging: a tool for evidence-based studies of nutrition?
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    Nutrition reviews
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A primer on brain imaging techniques suitable for the assessment of the structure and function of the human brain, focusing on noninvasive techniques such as structural and functional magnetic resonance imaging, electroencephalographic, and magnetoencephalography is provided.
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The objective of the workshop, which took place on November 12-13, 2009, in Brussels, Belgium, was to obtain an overview of the current knowledge of science in the field of cognitive performance assessment and to identify knowledge gaps and opportunities related to nutritional approaches to improving brain function and cognitive performance.
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Distinct nutrient biomarker patterns detected in plasma are interpretable and account for a significant degree of variance in both cognitive function and brain volume.
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The proposed model provides a direct mechanism to couple synaptic activity with glucose use and is consistent with the notion that the signals detected during physiological activation with 18F-deoxyglucose (DG)-PET may reflect predominantly uptake of the tracer into astrocytes.
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Utility of imaging for nutritional intervention studies in Alzheimer's disease.
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These findings are among the first to show that human brain structure can be influenced by early nutrition, and may partly explain the effects of early diet on cognition and the predominant effects in males.