Brain hydrogen sulfide is severely decreased in Alzheimer's disease.

  title={Brain hydrogen sulfide is severely decreased in Alzheimer's disease.},
  author={Ko Eto and Takashi Asada and Kunimasa Arima and Takao Makifuchi and Hideo Kimura},
  journal={Biochemical and biophysical research communications},
  volume={293 5},
Although hydrogen sulfide (H2S) is generally thought of in terms of a poisonous gas, it is endogenously produced in the brain from cysteine by cystathionine beta-synthase (CBS). H2S functions as a neuromodulator as well as a smooth muscle relaxant. Here we show that the levels of H2S are severely decreased in the brains of Alzheimer's disease (AD) patients compared with the brains of the age matched normal individuals. In addition to H2S production CBS also catalyzes another metabolic pathway… CONTINUE READING
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