Brain heterotrimeric Gαi₂-subunit protein-gated pathways mediate central sympathoinhibition to maintain fluid and electrolyte homeostasis during stress.

@article{Kapusta2012BrainHG,
  title={Brain heterotrimeric Gαi₂-subunit protein-gated pathways mediate central sympathoinhibition to maintain fluid and electrolyte homeostasis during stress.},
  author={Daniel R. Kapusta and Crissey L. Pascale and Richard David Wainford},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2012},
  volume={26 7},
  pages={2776-87}
}
Fluid and electrolyte homeostasis is integral to blood pressure regulation. However, the central molecular mechanisms regulating the neural control of sodium excretion remain unclear. We have demonstrated that brain Gαi(2)-subunit protein pathways mediate the natriuretic response to α(2)-adrenoreceptor activation in vivo. Consequently, we examined the role of brain Gαi(2) proteins in the neural mechanisms facilitating fluid and electrolyte homeostasis in response to acute [i.v. volume expansion… CONTINUE READING
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