Brain heparanase expression is up-regulated during postnatal development and hypoxia-induced neovascularization in adult rats.

@article{Navarro2008BrainHE,
  title={Brain heparanase expression is up-regulated during postnatal development and hypoxia-induced neovascularization in adult rats.},
  author={Fabrice P Navarro and Raafat P. Fares and Pascal E. Sanchez and J{\'e}r{\'e}mie Nadam and B{\'e}atrice Georges and Colette Moulin and Anne Morales and J N Pequignot and Laurent Bezin},
  journal={Journal of neurochemistry},
  year={2008},
  volume={105 1},
  pages={34-45}
}
Heparanase is an endo-beta-d-glucuronidase which specifically cleaves extracellular and cell surface heparan sulphates at intra-chain sites. Its enzymatic activity is strongly implicated in cell dissemination associated with tumor metastasis and inflammation. Indeed, heparanase gene is expressed in various tumors and its over-expression is correlated with increased tumor vascularity and metastatic potential of tumor cells. However, heparanase expression in non-invasive and non-immune tissue… CONTINUE READING

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