Brain gray and white matter volume loss accelerates with aging in chronic alcoholics: a quantitative MRI study.

@article{Pfefferbaum1992BrainGA,
  title={Brain gray and white matter volume loss accelerates with aging in chronic alcoholics: a quantitative MRI study.},
  author={Adolf Pfefferbaum and Kelvin O. Lim and Robert B Zipursky and Daniel H. Mathalon and Margaret J. Rosenbloom and Benjamin F. Lane and Chung Nim Ha and Edith V. Sullivan},
  journal={Alcoholism, clinical and experimental research},
  year={1992},
  volume={16 6},
  pages={1078-89}
}
Magnetic resonance imaging (MRI) was used to study in vivo the brains of 49 patients with chronic alcoholism, 3 to 4 weeks post-withdrawal, and 43 normal healthy controls, all right-handed male veterans between the ages of 23 and 70 years. MRI scans were analyzed using a semi-automated procedure, which allowed the subcortical regions to be segmented into cerebrospinal fluid (CSF) and brain tissue and the cortical regions to be segmented into CSF, gray matter, and white matter. An age regression… CONTINUE READING
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