Brain function in epilepsy: midbrain, medullary, and cerebellar interaction with the rostral forebrain.

@article{Heath1976BrainFI,
  title={Brain function in epilepsy: midbrain, medullary, and cerebellar interaction with the rostral forebrain.},
  author={Robert G. Heath},
  journal={Journal of Neurology, Neurosurgery \& Psychiatry},
  year={1976},
  volume={39},
  pages={1037 - 1051}
}
  • R. Heath
  • Published 1 November 1976
  • Psychology, Biology, Medicine
  • Journal of Neurology, Neurosurgery & Psychiatry
Against the background previous findings in epileptic patients, in whom electroencephalographic recordings were obtained from numerous deep and surface brain sites during seizures, rhesus monkeys with electrodes implanted into specific brain sites were used to demonstrate anatomical connections by evoked potential techniques and to serve as models of experimental epilepsy. In the animals, many monosynaptic connections were revealed between forebrain sites consistently involved in seizures in… 

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References

SHOWING 1-10 OF 36 REFERENCES

BRAIN FUNCTION AND BEHAVIOR: I. EMOTION AND SENSORY PHENOMENA IN PSYCHOTIC PATIENTS AND IN EXPERIMENTAL ANIMALS

  • R. Heath
  • Psychology, Medicine
    The Journal of nervous and mental disease
  • 1975
The data reported substantiate an anatomical localization in the brain for the syndrome of psychotic behavior and provide a basis for the development of specific biological methods for the treatment of behavioral disorders.

Correlation of brain function with emotional behavior.

  • R. Heath
  • Psychology, Medicine
    Biological psychiatry
  • 1976
Establishing the neurophysiologic basis for emotion has led to effective treatment for some neurologic and psychiatric disorders and provided a basis for defining the origin of certain clinical disorders that are still obscure, the first step toward development of their specific treatment.

Correlation of brain function with emotional behavior.

Investigation of brain sites where physiologic activity was correlated with subjective emotional experiences in patients undergoing treatment provided a basis for defining the origin of certain clinical disorders that are still obscure, the first step toward development of their specific treatment.

Stereotaxic Implantation of Electrodes in the Human Brain: A Method for Long-Term Study and Treatment

A stereotaxic method for placement of electrodes in the human brain is described. Radiographic visualization of subcortical targets are discussed and error correction formulas are developed.

Anatomic connections of the fastigial nucleus to the rostral forebrain in the cat.

Ascending projections of the cerebellar fastigial nuclei: connections to the ectosylvian gyrus.

Clinical and Physiological Effects of Stimulation of the Paleocerebellum in Humans

Chronically implanted electrodes allowed the repeated stimulation, with different rates and intensities and for variable durations, of the paleocerebellum in 4 patients with intractable muscular

Brain activity during emotional states.

Findings substantiate previous observations made in the Tulane University depth electrode series and add meaning to anatomic and physiologic data from animal studies that have shown an integral relationship between brain sites involved in sensory perception and those for emotional expression.