Brain fuel metabolism, aging, and Alzheimer's disease.

  title={Brain fuel metabolism, aging, and Alzheimer's disease.},
  author={Stephen C. Cunnane and S. Nugent and Maggie Roy and Alexandre Courchesne-Loyer and Etienne Croteau and S{\'e}bastien Tremblay and Alex Castellano and Fabien Pifferi and Christian Bocti and Nancy Paquet and Hadi Begdouri and M'hamed Bentourkia and {\'E}ric Turcotte and Mich{\`e}le Allard and Pascale Barberger-Gateau and Tamas Z Fulop and Stanley I. Rapoport},
  volume={27 1},
Lower brain glucose metabolism is present before the onset of clinically measurable cognitive decline in two groups of people at risk of Alzheimer's disease--carriers of apolipoprotein E4, and in those with a maternal family history of AD. Supported by emerging evidence from in vitro and animal studies, these reports suggest that brain hypometabolism may precede and therefore contribute to the neuropathologic cascade leading to cognitive decline in AD. The reason brain hypometabolism develops… CONTINUE READING
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