Brain from bone: efficient "meta-differentiation" of marrow stroma-derived mature osteoblasts to neurons with Noggin or a demethylating agent.

@article{Kohyama2001BrainFB,
  title={Brain from bone: efficient "meta-differentiation" of marrow stroma-derived mature osteoblasts to neurons with Noggin or a demethylating agent.},
  author={Jun Kohyama and Hitoshi Abe and Takuya Shimazaki and Amane Koizumi and Kinichi Nakashima and Satoshi Gojo and Takashi Taga and Hideyuki Okano and Jun-ichi Hata and Akihiro Umezawa},
  journal={Differentiation; research in biological diversity},
  year={2001},
  volume={68 4-5},
  pages={235-44}
}
Bone marrow stromal cells are able to differentiate into adipogenic, chondrogenic, myogenic, osteogenic, and cardiomyogenic lineages, all of which are limited to a mesoderm-derived origin. In this study, we showed that neurons, which are of an ectoderm-origin, could be generated from marrow-derived stromal cells by specific inducers, fibronectin/ornithine coating, and neurosphere formation. The neurons generated from marrow stroma formed neurites, expressed neuron-specific markers and genes… CONTINUE READING
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