Brain fodrin: substrate for calpain I, an endogenous calcium-activated protease.

@article{Siman1984BrainFS,
  title={Brain fodrin: substrate for calpain I, an endogenous calcium-activated protease.},
  author={Robert A Siman and Michel Baudry and Gary S. Lynch},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1984},
  volume={81 11},
  pages={3572-6}
}
The calcium-activated thiol-protease calpain I, which is present in cytosolic and membrane preparations from rat brain, was tested for its capacity to degrade the neuronal spectrin-like protein fodrin. In the presence of micromolar calcium concentrations purified calpain I degraded both purified fodrin and the fodrin present in hippocampal and cerebellar membranes. Fodrin was identified as a high molecular weight protein present in brain membranes by the following criteria: (i) comigration on… CONTINUE READING