Brain ferritin iron as a risk factor for age at onset in neurodegenerative diseases.

@article{Bartzokis2004BrainFI,
  title={Brain ferritin iron as a risk factor for age at onset in neurodegenerative diseases.},
  author={George Bartzokis and Todd A. Tishler and Il-seon Shin and P. H. Lu and Jeffrey L. Cummings},
  journal={Annals of the New York Academy of Sciences},
  year={2004},
  volume={1012},
  pages={224-36}
}
Tissue iron can promote oxidative damage. Brain iron increases with age and is abnormally elevated early in the disease process in several neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD). Higher iron levels in males may contribute to higher risk for younger-onset PD and recent studies have linked the presence of the hemochromatosis gene with a younger age at onset of AD. We examined whether age at onset of PD and AD was associated with increased… CONTINUE READING

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