Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model.

@article{Yue2005BrainED,
  title={Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model.},
  author={Xiangjun Yue and Melissa West Lu and Techie Lancaster and Phillip Cao and Shin-ichiro Honda and Matthias Staufenbiel and Nobuhiro Harada and Zhenyu Zhong and Yong Shen and Rena Li},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 52},
  pages={
          19198-203
        }
}
Much evidence indicates that women have a higher risk of developing Alzheimer's disease (AD) than do men. The reason for this gender difference is unclear. We hypothesize that estrogen deficiency in the brains of women with AD may be a key risk factor. In rapidly acquired postmortem brains from women with AD, we found greatly reduced estrogen levels compared with those from age- and gender-matched normal control subjects; AD and control subjects had comparably low levels of serum estrogen. We… CONTINUE READING

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