Brain engraftment of autologous macrophages transduced with a lentiviral flap vector: an approach to complement brain dysfunctions

@article{Mordelet2002BrainEO,
  title={Brain engraftment of autologous macrophages transduced with a lentiviral flap vector: an approach to complement brain dysfunctions},
  author={Elodie Mordelet and Karima Kissa and C-F Calvo and Ma{\"i} Lebastard and Genevi{\`e}ve Milon and Sylvie van der Werf and Christopher Vidal and Pierre Charneau},
  journal={Gene Therapy},
  year={2002},
  volume={9},
  pages={46-52}
}
Transplantation of ex vivo gene-corrected autologous cells represents an attractive therapeutic approach for brain diseases. Among the cells of the central nervous system, brain macrophages are promising candidates due to their role in tissue homeostasis and their implication in several neurological diseases. Up to now, gene transfer into macrophages has proven difficult by most currently available gene delivery methods. We describe herein, an efficient transduction of rat bone marrow-derived… CONTINUE READING
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