Brain endolases as specific markers of neuronal and glial cells.

@article{Schmechel1978BrainEA,
  title={Brain endolases as specific markers of neuronal and glial cells.},
  author={Donald E. Schmechel and Paul J. Marangos and Athanasios P. Zis and Milton W. Brightman and Frederick K. Goodwin},
  journal={Science},
  year={1978},
  volume={199 4326},
  pages={313-5}
}
There are three distinct enolase isoenzymes in brain; neuron-specific enolase (NSE), formerly referred to as neuron-specific protein, which is specifically localized in neurons, a nonneuronal enolase (NNE), and a third hybrid form. Light microscopy with immunocytochemical techniques has permitted localization of non-neuronal enolase. The NNE is located in glial cells with no staining of endothelial cells or neurons. Thus, NSE and NNE can be used as specific metabolic markers for neurons and… CONTINUE READING

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