Brain drug targeting and gene technologies.

  title={Brain drug targeting and gene technologies.},
  author={William M Pardridge},
  journal={Japanese journal of pharmacology},
  volume={87 2},
Brain drug targeting technology is based on the application of four gene technologies that enable the delivery of drugs or genes across the blood-brain barrier (BBB) in vivo. I) Genetic engineering is used to produce humanized monoclonal antibodies that target endogenous BBB transporters and act as vectors for delivery of drugs or genes to the human brain. The conjugate of a neurotherapeutic and a BBB transport vector is called a chimeric peptide. Epidermal growth factor chimeric peptides have… CONTINUE READING