Brain dopamine and obesity

@article{Wang2001BrainDA,
  title={Brain dopamine and obesity},
  author={Gene-Jack Wang and Nora D. Volkow and Jean Logan and Naoml R Pappas and Christopher T. Wong and Wel Zhu and Noelwah Netusll and Joanna S. Fowler},
  journal={The Lancet},
  year={2001},
  volume={357},
  pages={354-357}
}
BACKGROUND The cerebral mechanisms underlying the behaviours that lead to pathological overeating and obesity are poorly understood. Dopamine, a neurotransmitter that modulates rewarding properties of food, is likely to be involved. To test the hypothesis that obese individuals have abnormalities in brain dopamine activity we measured the availability of dopamine D2 receptors in brain. METHODS Brain dopamine D2 receptor availability was measured with positron emission tomography (PET) and [C… 
Altered Dopamine Synaptic Markers in Postmortem Brain of Obese Subjects
TLDR
Neurobiological changes in presynaptic DA markers demonstrated postmortem in human brain support a link between hedonic DA dysregulation and obesity.
Dopamine D2/3 receptor availability and amphetamine-induced dopamine release in obesity
TLDR
The preliminary data that obesity is associated with blunted dopamine release is provided and the positive correlation between dopamine release and food craving in obesity may seem contradictory with the latter finding but is presumably related to heterogeneity within the obese subjects.
Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: Possible contributing factors
TLDR
Assessment of the relationship between dopamine D2 receptor availability in striatum with brain glucose metabolism in obese subjects and controls suggested that decreases in striatal D2 receptors could contribute to overeating via their modulation of striatal prefrontal pathways, which participate in inhibitory control and salience attribution.
Relationship of Dopamine Type 2 Receptor Binding Potential With Fasting Neuroendocrine Hormones and Insulin Sensitivity in Human Obesity
TLDR
Evidence is provided for an association between the neuroendocrine hormones and DA brain signaling in obese females and the increased D2R availability in obese subjects reflects relatively reduced DA levels competing with the radioligand.
Effects of intravenous glucose on dopaminergic function in the human brain in vivo
TLDR
Gender differences were not among the a priori hypotheses of the present study and, therefore, they must be considered to be preliminary findings, and postulate that this observation is a reflection of an interaction between glucose, sex steroids (estrogen), leptin, and dopamine.
Striatal dopamine D2-like receptor correlation patterns with human obesity and opportunistic eating behavior
TLDR
The results suggest that obese people have alterations in dopamine neurocircuitry that may increase their susceptibility to opportunistic overeating while at the same time making food intake less rewarding, less goal directed and more habitual.
The role of central dopamine and serotonin in human obesity: lessons learned from molecular neuroimaging studies.
TLDR
It is concluded that obesity is associated with decreased central dopaminergic and serotonergic signaling and that future research, especially in long-term follow-up and interventional settings, is needed to advance the understanding of the neuronal pathophysiology of obesity in humans.
Central serotonin and dopamine transporters in overeating, obesity and insulin resistance
The objectives of this thesis were to study cerebral serotonin transporters (SERT) in the diencephalon and striatal dopamine transporters (DAT) in humans in different metabolic conditions (i.e. lean,
Reduced Insulin Sensitivity Is Related to Less Endogenous Dopamine at D2/3 Receptors in the Ventral Striatum of Healthy Nonobese Humans
TLDR
In healthy individuals, diminished insulin sensitivity is related to less endogenous dopamine at dopamine D2/3 receptor in the ventral striatum, and acute dopamine depletion reduces insulin sensitivity.
Are dopaminergic genotypes risk factors for eating behavior and obesity in adults?
TLDR
It is demonstrated that eating behavior might have an effect on obesity and dopaminergic polymorphisms could be risk factors for the development of obesity in Turkish population.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 29 REFERENCES
Striatal D 2 dopamine receptor binding characteristics in vivo in patients with alcohol dependence
Striatal D 2 dopamine receptor characteristics of nine male patients with alcohol dependence abstinent for t -68 weeks and eight healthy male volunteers were studied in vivo with positron emission
Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers
TLDR
When compared to normal controls, cocaine abusers showed significant decreases in dopamine D2 receptor availability which persisted 3‐4 months after detoxification, and these decreases were associated with decreased metabolism in several regions of the frontal of these brain areas which are involved in the channeling of drive and affect.
Dopamine D2 Receptor Availability in Opiate-Dependent Subjects before and after Naloxone-Precipitated Withdrawal
TLDR
This study documents decreases in D2 receptors in opiate-dependent subjects but does not document significant changes in striatal DA concentration during acute withdrawal.
Brain neurotransmitters in food and drug reward.
  • B. G. Hoebel
  • Biology, Medicine
    The American journal of clinical nutrition
  • 1985
TLDR
Current studies suggest a limbic system framework of chemical neuroanatomy in which peptides play an important role in the control of eating and behavior reinforcement, and the behavioral effects of foods and drugs can now be partially understood in the context of functional neuroan atomy.
Reproducibility of repeated measures of endogenous dopamine competition with [11C]raclopride in the human brain in response to methylphenidate.
  • G. Wang, N. Volkow, +5 authors N. Netusil
  • Medicine
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • 1999
TLDR
MP-induced changes in striatal DV and in Bmax/Kd, as well as the behavioral and cardiovascular effects, were reproducible with repeated administration.
D2 dopamine receptor gene and obesity.
TLDR
The data showing an association of the minor allele of the DRD2 gene with phenotypic characteristics suggest that this gene, located on q22-q23 region of chromosome 11, confers susceptibility to a subtype of this disorder.
Mesolimbic dopaminergic system activity as a function of food reward: A microdialysis study
TLDR
The results indicate that the MDS is activated on ingestion of food, and suggest that MDS activity is related to the rewarding properties of foods.
Allelic association of the D2 dopamine receptor gene with receptor-binding characteristics in alcoholism.
TLDR
The polymorphic pattern of the D2 dopamine receptor gene and its differential expression of receptors suggests the involvement of the dopaminergic system in conferring susceptibility to at least one subtype of severe alcoholism.
Differential responsiveness of dopamine transmission to food-stimuli in nucleus accumbens shell/core compartments
TLDR
Monitoring the changes in dopamine transmission in the nucleus accumbens shell and core during appetitive and consummatory phases of behaviour motivated by food suggests that phasic dopamine Transmission in each compartment of the nucleus Accumbens subserves different roles in motivated behaviour.
Quantitative analysis of D2 dopamine receptor binding in the living human brain by PET.
TLDR
Studies of [11C]raclopride binding indicate that clinically effective doses of chemically distinct neuroleptic drugs result in 85 to 90 percent occupancy of D2 dopamine receptors in the putamen of schizophrenic patients.
...
1
2
3
...