Brain development under stress: Hypotheses of glucocorticoid actions revisited

  title={Brain development under stress: Hypotheses of glucocorticoid actions revisited},
  author={Melly S. Oitzl and Danielle L. Champagne and Rixt van der Veen and Edo Ronald de Kloet},
  journal={Neuroscience \& Biobehavioral Reviews},

A double-hit model of stress dysregulation in rats: implications for limbic corticosteroid receptors and anxious behavior under amitriptyline treatment

The differential effects among groups could mean that MS would promote an alternative phenotype that is expressed when facing CVS (a double hit) later in life.

Stress Research : Past , Present , and Future

The evolution of the stress concept and the discovery of mediators that coordinate highlighting stress adaptation are discussed and five highlights that illustrate the serendipitous nature of stress research are presented, which culminates in reflections on the role of stress in mental health.

The infralimbic mineralocorticoid blockage prevents the stress-induced impairment of aversive memory extinction in rats

It is observed that acutely restraint-stressed male Wistar rats showed high corticosterone (CORT) levels, and previous intra-IL-spironolactone administration (a selective MR antagonist) decreased it 60 min after the stress started, suggesting that the IL-MR activity controls CORT concentration, and it is crucial to the establishment of late extinction impairment.

Stress effects on memory: An update and integration

The Developmental Psychobiology of Stress and Emotion in Childhood

Under what conditions does stress exposure in childhood induce vulnerability, and when does it promote resilience? In this chapter we review what is known about the developmental psychobiology of

Female HPA axis displays heightened sensitivity to pre-pubertal stress

Using a rodent model, it is shown that the female stress system is more reactive to the lasting effects of early life stress, which may help explain why in humans females display an increased susceptibility to certain stress-related psychopathologies.



Physiology and neurobiology of stress and adaptation: central role of the brain.

  • B. McEwen
  • Psychology, Biology
    Physiological reviews
  • 2007
As an adjunct to pharmaceutical therapy, social and behavioral interventions such as regular physical activity and social support reduce the chronic stress burden and benefit brain and body health and resilience.

Stress and the brain: from adaptation to disease

New candidate susceptibility genes that serve as markers for the prediction of vulnerable phenotypes are now being identified in genetically predisposed individuals.

Mood disorders and allostatic load

  • B. McEwen
  • Psychology, Biology
    Biological Psychiatry
  • 2003

Protective and Damaging Effects of Mediators of Stress: Elaborating and Testing the Concepts of Allostasis and Allostatic Load

Allostatic load reflects not only the impact of life experiences but also of genetic load; individual habits reflecting items such as diet, exercise, and substance abuse; and developmental experiences that set life‐long patterns of behavior and physiological reactivity.

Brain corticosteroid receptor balance in health and disease.

The balance in actions mediated by the two corticosteroid receptor types in these neurons appears critical for neuronal excitability, stress responsiveness, and behavioral adaptation and Dysregulation of this MR/GR balance brings neurons in a vulnerable state with consequences for regulation of the stress response and enhanced vulnerability to disease in genetically predisposed individuals.

Physiological functions of glucocorticoids in stress and their relation to pharmacological actions.

It is proposed that stress-induced increases in glucocorticoid levels protect not against the source of stress itself but rather against the body's normal reactions to stress, preventing those reactions from overshooting and themselves threatening homeostasis.