Brain development during childhood and adolescence: a longitudinal MRI study

@article{Giedd1999BrainDD,
  title={Brain development during childhood and adolescence: a longitudinal MRI study},
  author={Jay N. Giedd and Jonathan D. Blumenthal and Neal O. Jeffries and Francisco Xavier Castellanos and H Liu and A. Zijdenbos and Tom{\'a}{\vs} Paus and Alan C. Evans and Judith L. Rapoport},
  journal={Nature Neuroscience},
  year={1999},
  volume={2},
  pages={861-863}
}
Pediatric neuroimaging studies, up to now exclusively cross sectional, identify linear decreases in cortical gray matter and increases in white matter across ages 4 to 20. In this large-scale longitudinal pediatric neuroimaging study, we confirmed linear increases in white matter, but demonstrated nonlinear changes in cortical gray matter, with a preadolescent increase followed by a postadolescent decrease. These changes in cortical gray matter were regionally specific, with developmental… 
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