Brain-derived neurotrophic factor triggers transcription-dependent, late phase long-term potentiation in vivo.

  title={Brain-derived neurotrophic factor triggers transcription-dependent, late phase long-term potentiation in vivo.},
  author={ElHoucine Messaoudi and Shui-Wang Ying and Tambudzai Kanhema and Susan D. Croll and Clive R Bramham},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={22 17},
Acute intrahippocampal infusion of brain-derived neurotrophic factor (BDNF) leads to long-term potentiation (BDNF-LTP) of synaptic transmission at medial perforant path-->granule cell synapses in the rat dentate gyrus. Endogenous BDNF is implicated in the maintenance of high-frequency stimulation-induced LTP (HFS-LTP). However, the relationship between exogenous BDNF-LTP and HFS-LTP is unclear. First, we found that BDNF-LTP, like HFS-LTP, is associated with enhancement in both synaptic strength… CONTINUE READING
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BDNF-induced long-term potentiation in the dentate gyrus in vivo is associated with phosphorylation of elongation factor-2

  • T Kanhema, SW Ying, AC Nairn, CR Bramham
  • Soc Neurosci Abstr
  • 2001
Highly Influential
4 Excerpts

The role of extracellular regulated kinases I / II in late - phase long - term potentiation

  • AF Schinder, MM Poo
  • J Neurosci
  • 2000
Highly Influential
4 Excerpts

Arc, a neuronal immediate early gene, interacts with the association domain of CaMKII

  • S Chowdhury, GL Lyford, O Steward, C Wallace, A Lanahan, P Worley
  • Soc Neurosci Abstr
  • 1998
Highly Influential
3 Excerpts

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