Brain-derived neurotrophic factor triggers transcription-dependent, late phase long-term potentiation in vivo.

@article{Messaoudi2002BrainderivedNF,
  title={Brain-derived neurotrophic factor triggers transcription-dependent, late phase long-term potentiation in vivo.},
  author={ElHoucine Messaoudi and Shui-Wang Ying and Tambudzai Kanhema and Susan D. Croll and Clive R Bramham},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 17},
  pages={7453-61}
}
Acute intrahippocampal infusion of brain-derived neurotrophic factor (BDNF) leads to long-term potentiation (BDNF-LTP) of synaptic transmission at medial perforant path-->granule cell synapses in the rat dentate gyrus. Endogenous BDNF is implicated in the maintenance of high-frequency stimulation-induced LTP (HFS-LTP). However, the relationship between exogenous BDNF-LTP and HFS-LTP is unclear. First, we found that BDNF-LTP, like HFS-LTP, is associated with enhancement in both synaptic strength… CONTINUE READING
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