Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex.

@article{Croll1999BrainderivedNF,
  title={Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex.},
  author={Susan D. Croll and Chitra Suri and Donald L. Compton and Mary V Simmons and George D. Yancopoulos and Ronald M. Lindsay and Stanley J. Wiegand and John S. Rudge and Helen E Scharfman},
  journal={Neuroscience},
  year={1999},
  volume={93 4},
  pages={1491-506}
}
Transgenic mice overexpressing brain-derived neurotrophic factor from the beta-actin promoter were tested for behavioral, gross anatomical and physiological abnormalities. Brain-derived neurotrophic factor messenger RNA overexpression was widespread throughout brain. Overexpression declined with age, such that levels of overexpression decreased sharply by… CONTINUE READING