Brain-derived neurotrophic factor rapidly increases AMPA receptor surface expression in rat nucleus accumbens.

@article{Li2011BrainderivedNF,
  title={Brain-derived neurotrophic factor rapidly increases AMPA receptor surface expression in rat nucleus accumbens.},
  author={Xuan Li and Marina E Wolf},
  journal={The European journal of neuroscience},
  year={2011},
  volume={34 2},
  pages={190-8}
}
In the rodent nucleus accumbens (NAc), cocaine elevates levels of brain-derived neurotrophic factor (BDNF). Conversely, BDNF can augment cocaine-related behavioral responses. The latter could reflect enhancement of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) transmission, because AMPARs in the NAc mediate some cocaine-induced behaviors. Furthermore, in vitro studies in other cell types show that BDNF can promote AMPAR synaptic delivery. In this study, we investigated… CONTINUE READING