Brain-derived neurotrophic factor protects against ischemic cell damage in rat hippocampus.


The neuroprotective action of brain-derived neurotrophic factor (BDNF) was evaluated in a rat model of transient forebrain ischemia. A continuous intraventricular infusion of BDNF for 7 days starting immediately before the onset of ischemia significantly increased the number of pyramidal cells in the vulnerable CA1 sector of the hippocampus. In situ hybridization experiments suggest the neuroprotection to be mediated via trkB-receptors in the hippocampus. The data indicate a therapeutic potential for the treatment of cerebral ischemia.

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@article{Beck1994BrainderivedNF, title={Brain-derived neurotrophic factor protects against ischemic cell damage in rat hippocampus.}, author={Tino Beck and Dan Lindholm and Eero Castr{\'e}n and Andreas Wree}, journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism}, year={1994}, volume={14 4}, pages={689-92} }