Brain-derived neurotrophic factor promotes differentiation of striatal GABAergic neurons.

@article{Mizuno1994BrainderivedNF,
  title={Brain-derived neurotrophic factor promotes differentiation of striatal GABAergic neurons.},
  author={Kiyonobu Mizuno and Josette Carnahan and Hiroyuki Nawa},
  journal={Developmental biology},
  year={1994},
  volume={165 1},
  pages={243-56}
}
The influence of neurotrophins on GABAergic properties of developing striatal neurons was investigated both in vivo and in vitro. Brain-derived neurotrophic factor (BDNF) specifically elevated cellular GABA content in striatal culture without altering neuronal survival. Neurotrophin-5 produced a similar effect on GABA, but nerve growth factor and neurotrophin-3 had no effect. An increase in GABA content in the striatum was also observed following BDNF injections into the cerebroventricle of… CONTINUE READING

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