Brain-derived neurotrophic factor modulates angiotensin signaling in the hypothalamus to increase blood pressure in rats.

@article{Erdos2015BrainderivedNF,
  title={Brain-derived neurotrophic factor modulates angiotensin signaling in the hypothalamus to increase blood pressure in rats.},
  author={Benedek Erdos and Iara M. Backes and Michael L. McCowan and Linda Hayward and Deborah A. Scheuer},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2015},
  volume={308 6},
  pages={H612-22}
}
Brain-derived neurotrophic factor (BDNF) expression increases in the paraventricular nucleus of the hypothalamus (PVN) in response to hypertensive stimuli including stress and hyperosmolarity. However, it is unclear whether BDNF in the PVN contributes to increases in blood pressure (BP). We tested the hypothesis that increased BDNF levels within the PVN would elevate baseline BP and heart rate (HR) and cardiovascular stress responses by altering central angiotensin signaling. BP was recorded… CONTINUE READING
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