Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume.

@article{Erickson2010BrainderivedNF,
  title={Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume.},
  author={Kirk I. Erickson and Ruchika Shaurya Prakash and Michelle W. Voss and Laura Chaddock and Susie Heo and Molly E. McLaren and Brandt D. Pence and Stephen A. Martin and Victoria J Vieira and Jeffrey A. Woods and Edward McAuley and Arthur F. Kramer},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 15},
  pages={5368-75}
}
Hippocampal volume shrinks in late adulthood, but the neuromolecular factors that trigger hippocampal decay in aging humans remains a matter of speculation. In rodents, brain-derived neurotrophic factor (BDNF) promotes the growth and proliferation of cells in the hippocampus and is important in long-term potentiation and memory formation. In humans, circulating levels of BDNF decline with advancing age, and a genetic polymorphism for BDNF has been related to gray matter volume loss in old age… CONTINUE READING

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