Brain-derived neurotrophic factor is an endogenous modulator of nociceptive responses in the spinal cord.

Abstract

The primary sensory neurons that respond to noxious stimulation and project to the spinal cord are known to fall into two distinct groups: one sensitive to nerve growth factor and the other sensitive to glial cell-line-derived neurotrophic factor. There is currently considerable interest in the ways in which these factors may regulate nociceptor properties… (More)

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